Today on the Evolution of Medicine podcast, we go back to the first Evolution of Medicine Summit with Dr. David Perlmutter, a renowned neurologist, brain health expert,  and best selling author. He joined us to speak about the ever important, gut brain connection. We review this presentation in preparation for the upcoming Functional Forum - The Evolution of Neurology where will be bring you the best highlights from the Institute for Functional Medicine Annual International Conference. 
^ Hayward, Rhodri (2011). "Medicine and the Mind". In Jackson, Mark. The Oxford Handbook of the History of Medicine. Oxford University Press. pp. 524–42. ISBN 978-0199546497.; Scull, Andrew (2005). Most Solitary of Afflictions: Madness And Society in Britain, 1700–1900. Yale University Press. pp. 324–28. ISBN 978-0300107548.; Dowbiggin, I. (1992). ""An exodus of enthusiasm": G. Alder Blumer, eugenics, and US psychiatry, 1890–1920". Medical History. 36 (4): 379–402. doi:10.1017/S002572730005568X. PMC 1036631. PMID 1435019.; Snelders, S.; Meijman, F.J.; Pieters, T. (2007). "Heredity and alcoholism in the medical sphere: The Netherlands, 1850–1900". Medical History. 51 (2): 219–36. doi:10.1017/S0025727300001204. PMC 1871693. PMID 17538696.; Turda, M. (2009). ""To end the degeneration of a nation": Debates on eugenic sterilization in inter-war Romania". Medical History. 53 (1): 77–104. doi:10.1017/S002572730000332X. PMC 2629178. PMID 19190750.
Couldn’t agree more about the cost of functional medicine tests being problematic (and the fact that mainstream medicine does not cover the cost), really glad you raised this Chris as being a health detective for ones own health quickly becomes really expensive. So was really intrigued to hear that there is a functional medicine approach working in rural Indiana. If this is going to be a real health revolution then it needs to be one that is accessible to the very average person.
James Maskell:  Absolutely.  The evolutionary concepts were one of the big reasons why I wanted you to be in there, Chris, because I know you do the Paleo, which is evolutionary in itself.  But also, one of the things that you talk about is how the Paleo diet is something that has needed to change and evolve, and how we’ve evolved to go beyond what our ancestors ate.  I don’t know, maybe for your listeners, they might be interested to just get a snapshot of that.  Because that’s one of the cool things in nutrition that I think that you bring together, is a very sensible approach to eating. I thought that was one of the highlights for the nutrition part of the summit.
Hippocrates and his followers were first to describe many diseases and medical conditions. Though humorism (humoralism) as a medical system predates 5th-century Greek medicine, Hippocrates and his students systemetized the thinking that illness can be explained by an imbalance of blood, phlegm, black bile, and yellow bile.[41] Hippocrates is given credit for the first description of clubbing of the fingers, an important diagnostic sign in chronic suppurative lung disease, lung cancer and cyanotic heart disease. For this reason, clubbed fingers are sometimes referred to as "Hippocratic fingers".[42] Hippocrates was also the first physician to describe the Hippocratic face in Prognosis. Shakespeare famously alludes to this description when writing of Falstaff's death in Act II, Scene iii. of Henry V.[43]
James Maskell is the host of our podcast and flagship show, the Functional Forum, the world’s largest integrative medicine community. He is on a mission to create structures necessary to evolve humanity beyond chronic disease. He lectures internationally and has been featured on TEDx, TEDMED and HuffPostLive and also founder of KNEW Health, a payer solution for chronic disease reversal.

^ Hamilton, William (1831). The history of medicine, surgery and anatomy. p. 358. Retrieved 24 December 2013. As a proof of his ignorance and his arrogance, he commenced his very first lecture by publicly consigning to the flames the works of Galen and Avicenna, impudently declaring that his cap contained more knowledge than all the physicians, and the hair of his beard more experience than all the universities in the world. "Greeks, Romans, French, and Italians," he exclaimed, "you Avicenna, you Galen, you Rhazes, you Mesne; you Doctors of Paris, of Montpellier, of Swabia, of Misnia, of Cologne, of Vienna, and all you through out the countries bathed by the Danube and the Rhine; and you who dwell in the islands of the sea, Athenian, Greek, Arab, and Jew! you shall all follow and obey me. I am your king; to me belongs the sceptre of physic."

The Department of the History of Medicine is the oldest such academic department in North America. We are dedicated to scholarship in the history of medicine, disease and the health sciences, and their relation to society. The Department seeks to bring historical perspectives to bear on contemporary health issues. Faculty members conduct research on a broad range of topics, time periods, and geographic areas. The Department offers a PhD in the History of Medicine.
Alfred Nobel (1833-1896), a Swedish-born chemist and businessman who invented dynamite, left most of his wealth to establish the Nobel Prizes. Since 1901, these awards have been given to men and women from all over the world in recognition of their outstanding achievements in chemistry, medicine or physiology, physics, literature and for work on behalf of peace.
Until the nineteenth century, the care of the insane was largely a communal and family responsibility rather than a medical one. The vast majority of the mentally ill were treated in domestic contexts with only the most unmanageable or burdensome likely to be institutionally confined.[152] This situation was transformed radically from the late eighteenth century as, amid changing cultural conceptions of madness, a new-found optimism in the curability of insanity within the asylum setting emerged.[153] Increasingly, lunacy was perceived less as a physiological condition than as a mental and moral one[154] to which the correct response was persuasion, aimed at inculcating internal restraint, rather than external coercion.[155] This new therapeutic sensibility, referred to as moral treatment, was epitomised in French physician Philippe Pinel's quasi-mythological unchaining of the lunatics of the Bicêtre Hospital in Paris[156] and realised in an institutional setting with the foundation in 1796 of the Quaker-run York Retreat in England.[23]
Ancient Egypt developed a large, varied and fruitful medical tradition. Herodotus described the Egyptians as "the healthiest of all men, next to the Libyans",[18] because of the dry climate and the notable public health system that they possessed. According to him, "the practice of medicine is so specialized among them that each physician is a healer of one disease and no more." Although Egyptian medicine, to a considerable extent, dealt with the supernatural,[19] it eventually developed a practical use in the fields of anatomy, public health, and clinical diagnostics.
^ Shorter, Edward (1997). A history of psychiatry: from the era of the asylum to the age of Prozac. John Wiley & Sons. pp. 46–48. ISBN 978-0471157496.; Bynum, W.F. (2006). "The Rise of Science in Medicine, 1850–1913". The Western Medical Tradition: 1800–2000. Hardy, Anne; Jacyna, Stephen; Lawrence, Christopher; Tansey, E.M. Cambridge University Press. pp. 198–99. ISBN 978-0521475655.
This week’s podcast features: Daniel Schmachtenburger, co-founder and director of research and development at Neurohacker Collective, in Complexity Medicine: The Basis for a Functional Standard of Care. Daniel is a deep thinker and researcher on how human regulatory systems function, how they break down and how they can be supported to function with greater resilience.
Medicine made huge advances in the 20th century. The first non-direct blood transfusion was made in 1914. Insulin was first used to treat a patient in 1922. The EEG machine was first used in 1929. Meanwhile many new drugs were developed. In 1910 the discovered salvarsan, a drug used to treat syphilis was discovered. In 1935 prontosil was used to treat blood poisoning. Later it was discovered that the active ingredient of the dye was a chemical called sulphonamide, which was derived from coal tar. As a result in the late 1930s a range of drugs derived from sulphonamide were developed.

This week on the Evolution of Medicine podcast continues our “Success Leaves Clues” series, “From Matrix to Action” and welcome former Functional Forum guest Dr. Lara Salyer of Health Innate. Dr. Salyer, DO was featured on the Functional Forum this year, is an enthusiastic member of our Practice Accelerator program, and runs a functional medicine practice in rural Wisconsin.
The Nightingale model was widely copied. Linda Richards (1841–1930) studied in London and became the first professionally trained American nurse. She established nursing training programs in the United States and Japan, and created the first system for keeping individual medical records for hospitalized patients.[121] The Russian Orthodox Church sponsored seven orders of nursing sisters in the late 19th century. They ran hospitals, clinics, almshouses, pharmacies, and shelters as well as training schools for nurses. In the Soviet era (1917–1991), with the aristocratic sponsors gone, nursing became a low-prestige occupation based in poorly maintained hospitals.[122]
Kan Aiya, a 60-year-old woman, had lost many loved ones to breast cancer. She had seen her sisters die of the cruel disease, so when a tumour formed in her left breast she was well aware of the likely outcome. For her, however, there was a chance of survival – an operation. It was 1804 and she was in the best possible place for surgery – feudal Japan.
A revolution of a new age of medicine. It is time to make lifestyle changes, improve our education on what we are putting into our bodies on a daily basis, how often do we get fresh air and exercise, how many hours of restful deep sleep do we receive each night? How about our stress levels? All of these and many more affect us intrinsically but most of us just wait for things to go wrong and then expect the medical professional to make us better. We have got this so wrong it is time to take back responsibility and learn what it truly means to look after our health...mentally, physically and socially. This book is pioneering this change and laying the foundations for the medical profession to step up to the challenge of providing the education and the support that we will all need to make this leap...
As noted in the table below, adaptationist hypotheses regarding the etiology of psychological disorders are often based on analogies with evolutionary perspectives on medicine and physiological dysfunctions (see in particular, Randy Nesse and George C. Williams' book Why We Get Sick).[43] Evolutionary psychiatrists and psychologists suggest that some mental disorders likely have multiple causes.[65]
Eminent French scientist Louis Pasteur confirmed Schwann's fermentation experiments in 1857 and afterwards supported the hypothesis that yeast were microorganisms. Moreover, he suggested that such a process might also explain contagious disease. In 1860, Pasteur's report on bacterial fermentation of butyric acid motivated fellow Frenchman Casimir Davaine to identify a similar species (which he called bacteridia) as the pathogen of the deadly disease anthrax. Others dismissed "bacteridia" as a mere byproduct of the disease. British surgeon Joseph Lister, however, took these findings seriously and subsequently introduced antisepsis to wound treatment in 1865.
1796 Edward Jenner develops a method to protect people from smallpox by exposing them to the cowpox virus. In his famous experiment, he rubs pus from a dairymaid's cowpox postule into scratches on the arm of his gardener's 8-year-old son, and then exposes him to smallpox six weeks later (which he does not develop). The process becomes known as vaccination from the Latin vacca for cow. Vaccination with cowpox is made compulsory in Britain in 1853. Jenner is sometimes called the founding father of immunology.
Chris Kresser:  So what kind of response are you getting?  I mean, it sounds like, just from the little bit that I’ve heard, that this is really happening at a big level, with The Huffington Post support.  You know, this is getting beyond the typical kind of blog tour that a lot of these summits do.  So what’s been the response in the more mainstream world to the whole concept of functional medicine and doing a summit on this topic?
I ended up selling the practice to my partner and taking a 20-month sabbatical due to a motor vehicle accident. I had considered retiring after selling the practice, but in the area where I live there are very few people practicing this style of medicine and the need far exceeds the number of people who have the skills or knowledge. During the time I was not working, I had many former patients contacting me and wanting to know when I was going to open a new practice.