On losing the 1883 rivalry in Alexandria, Pasteur switched research direction, and introduced his third vaccine—rabies vaccine—the first vaccine for humans since Jenner's for smallpox.[116] From across the globe, donations poured in, funding the founding of Pasteur Institute, the globe's first biomedical institute, which opened in 1888.[116] Along with Koch's bacteriologists, Pasteur's group—which preferred the term microbiology—led medicine into the new era of "scientific medicine" upon bacteriology and germ theory.[116] Accepted from Jakob Henle, Koch's steps to confirm a species' pathogenicity became famed as "Koch's postulates". Although his proposed tuberculosis treatment, tuberculin, seemingly failed, it soon was used to test for infection with the involved species. In 1905, Koch was awarded the Nobel Prize in Physiology or Medicine, and remains renowned as the founder of medical microbiology.[118]
In the 17th century medicine was helped by the microscope (invented at the end of the 16th century). Then in 1665 Robert Hooke was the first person to describe cells in his book Micrographia. Finally in 1683 Antonie van Leeuwenhoek observed microorganisms. However he did not realise they caused disease. Meanwhile in 1661 Robert Boyle published the Skeptical Chemist, which laid the foundations of modern chemistry. In the early 17th century doctors also discovered how to treat malaria with bark from the cinchona tree (it contains quinine).
This week, Dr. Wible joins us to talk about the epidemic of physician suicide. She's filmed a powerful TedMed talk on the epidemic of physician suicide where she read the words of physicians on the edge of taking their own lives. As we lose more brilliant minds and healers to suicide, Dr. Wible has started a project to bring this epidemic to light. Her film called "Do No Harm" will do exactly that and she tells us more about the film and how we can support the movement.
One curious method of providing the disease with means of escape from the body was by making a hole, 2.5 to 5 cm across, in the skull of the victim—the practice of trepanning, or trephining. Trepanned skulls of prehistoric date have been found in Britain, France, and other parts of Europe and in Peru. Many of them show evidence of healing and, presumably, of the patient’s survival. The practice still exists among some tribal people in parts of Algeria, in Melanesia, and perhaps elsewhere, though it is fast becoming extinct.
^ Jump up to: a b Askitopoulou, H.; Konsolaki, E.; Ramoutsaki, I.; Anastassaki, E. (2002). Surgical cures by sleep induction as the Asclepieion of Epidaurus. The history of anesthesia: proceedings of the Fifth International Symposium, by José Carlos Diz, Avelino Franco, Douglas R. Bacon, J. Rupreht, Julián Alvarez. Elsevier Science B.V., International Congress Series 1242. pp. 11–17. ISBN 978-0444512932.
The week on the Evolution of Podcast, we welcome Dr. Elson Haas, leader in the field of integrative medicine. After four decades of practicing integrative medicine in the insurance model, he provides us with some great insights into how he is able keep is practice going.​​ Dr. Haas' latest book Staying Healthy with NEW Medicine gives some insights on natural, Eastern, Western concepts into something that is truly useful for the modern practitioner and the modern patient. 
This week on the Evolution of Medicine podcast,  we hear from Richard Morris, CEO of Powell Metabolics. Powell Metabolics is an innovative wellness coaching program delivered in a physical therapy environment that started in Arizona and has the potential to expand across the country. This is part of a greater trend of functional medicine integrating with other "hands on" modalities like physical therapy, personal training and chiropractic. We think you'll be inspired to hear about their process, the results and how your practice could benefit.
Like all biological systems, both disease-causing organisms and their victims evolve. Understanding evolution can make a big difference in how we treat disease. The evolution of disease-causing organisms may outpace our ability to invent new treatments, but studying the evolution of drug resistance can help us slow it. Learning about the evolutionary origins of diseases may provide clues about how to treat them. And considering the basic processes of evolution can help us understand the roots of genetic diseases.
By the thirteenth century, the medical school at Montpellier began to eclipse the Salernitan school. In the 12th century, universities were founded in Italy, France, and England, which soon developed schools of medicine. The University of Montpellier in France and Italy's University of Padua and University of Bologna were leading schools. Nearly all the learning was from lectures and readings in Hippocrates, Galen, Avicenna, and Aristotle.

Later in Roman times Galen (130-200 AD) became a famous doctor. At first he worked treating wounded gladiators. Then in 169 AD he was made doctor to Commodus, the Roman Emperor's son. Galen was also a writer and he wrote many books. Galen believed the theory of the four humors. He also believed in treating illness with opposites. So if a patient had a cold Galen gave him something hot like pepper. Galen was also interested in anatomy. Unfortunately by his time dissecting human bodies was forbidden. So Galen had to dissect animal bodies including apes. However animal bodies are not the same as human bodies and so some of Galen's ideas were quite wrong. Unfortunately Galen was a very influential writer. For centuries his writings dominated medicine.

The earliest known physician is also credited to ancient Egypt: Hesy-Ra, "Chief of Dentists and Physicians" for King Djoser in the 27th century BCE.[26] Also, the earliest known woman physician, Peseshet, practiced in Ancient Egypt at the time of the 4th dynasty. Her title was "Lady Overseer of the Lady Physicians." In addition to her supervisory role, Peseshet trained midwives at an ancient Egyptian medical school in Sais.[citation needed]
Pasteur realized the germs that had been left exposed to the air had been weakened. When the chickens were injected with the weakened germs they had developed immunity to the disease. Pasteur and his team went on to create a vaccine for anthrax by keeping anthrax germs heated to 42-43 degrees centigrade for 8 days. In 1882 they created a vaccine for rabies. A co-worker dried the spines of rabbits that had contracted the disease in glass jars. Pasteur tried giving a series of injections made from the dried spines to animals to test the remedy. Then, in 1885, Pasteur successfully used the vaccine on a boy who had been bitten by a rabid dog. Pasteur also invented a way of sterilizing liquids by heating them (called pasteurization). It was first used for wine (in 1864) and later for milk.
James Maskell:  Absolutely.  Well, the concept with the Evolution of Medicine Summit was that I saw so many ways in which medicine was evolving.  You know, medicine is evolving to treat the kind of diseases that we have, the current epidemics.  So it’s having to sort of evolve and adapt to deal with that.  There are also really cool evolutionary concepts within medicine and health that I know you’re really big on.  And that’s why I had to have you come in and speak.  You know, obviously, I know you’re big on the microbiome, and our evolution with microbes has certainly been something that people are interested in, obviously evolutionary nutrition and then Paleo concepts.  We are really excited to have your talk as the keynote for the Paleo day on the summit.  And then there’s also this evolution with regards to technology as well, health technology and the interaction.  You’re right there in San Francisco, the Silicon Valley Revolution, which I really feel is a synergistic force to the work that we are all doing in integrative and functional medicine.  I just saw all of these things coming together.  They’re literally coming together in the first week of September.  There’s the iPhone, the new iWatch is going to launch then.  We have the Cleveland Clinic announcement with Functional Forum.  We have the Brain and Gut Journal coming up.  So all of these things are happening in the first week of September.  It’s just been really congruent to put together a summit of the finest minds and try and share some of these messages as quickly and as effectively as possible.
1899	Felix Hoffman develops aspirin (acetyl salicylic acid). The juice from willow tree bark had been used as early as 400 BC to relieve pain. 19th century scientists knew that it was the salicylic acid in the willow that made it work, but it irritated the lining of the mouth and stomach. Hoffman synthesizes acetyl salicylic acid, developing what is now the most widely used medicine in the world.

Greek historian Herodotus stated that every Babylonian was an amateur physician, since it was the custom to lay the sick in the street so that anyone passing by might offer advice. Divination, from the inspection of the liver of a sacrificed animal, was widely practiced to foretell the course of a disease. Little else is known regarding Babylonian medicine, and the name of not a single physician has survived.
Unethical human subject research, and killing of patients with disabilities, peaked during the Nazi era, with Nazi human experimentation and Aktion T4 during the Holocaust as the most significant examples. Many of the details of these and related events were the focus of the Doctors' Trial. Subsequently, principles of medical ethics, such as the Nuremberg Code, were introduced to prevent a recurrence of such atrocities.[176] After 1937, the Japanese Army established programs of biological warfare in China. In Unit 731, Japanese doctors and research scientists conducted large numbers of vivisections and experiments on human beings, mostly Chinese victims.[177]
The underlying principle of most medieval medicine was Galen's theory of humours. This was derived from the ancient medical works, and dominated all western medicine until the 19th century. The theory stated that within every individual there were four humours, or principal fluids—black bile, yellow bile, phlegm, and blood, these were produced by various organs in the body, and they had to be in balance for a person to remain healthy. Too much phlegm in the body, for example, caused lung problems; and the body tried to cough up the phlegm to restore a balance. The balance of humours in humans could be achieved by diet, medicines, and by blood-letting, using leeches. The four humours were also associated with the four seasons, black bile-autumn, yellow bile-summer, phlegm-winter and blood-spring.[75]
The Evolution of Medicine provides step-by-step instruction for building a successful "community micropractice", one that engages both the patient and practitioner in a therapeutic partnership focused on the body as a whole rather than isolated symptoms. This invaluable handbook will awaken health professionals to exciting new career possibilities. At the same time, it will alleviate the fear of abandoning a conventional medical system that is bad for doctors, patients, and payers, as well as being ineffectual in the treatment of chronic ailments.