Late antiquity ushered in a revolution in medical science, and historical records often mention civilian hospitals (although battlefield medicine and wartime triage were recorded well before Imperial Rome). Constantinople stood out as a center of medicine during the Middle Ages, which was aided by its crossroads location, wealth, and accumulated knowledge. copied content from Byzantine medicine; see that page's history for attribution

Upon the outbreak of a cholera epidemic in Alexandria, Egypt, two medical missions went to investigate and attend the sick, one was sent out by Pasteur and the other led by Koch.[116] Koch's group returned in 1883, having successfully discovered the cholera pathogen.[116] In Germany, however, Koch's bacteriologists had to vie against Max von Pettenkofer, Germany's leading proponent of miasmatic theory.[117] Pettenkofer conceded bacteria's casual involvement, but maintained that other, environmental factors were required to turn it pathogenic, and opposed water treatment as a misdirected effort amid more important ways to improve public health.[117] The massive cholera epidemic in Hamburg in 1892 devastasted Pettenkoffer's position, and yielded German public health to "Koch's bacteriology".[117]
James pieces together the last twenty five to forty years from the elders of which functional medicine was created. The basis of Functional Medicine is in history of Naturopathic, Chiropractic and Acupuncture along with the nutritional and medical research worlds. The new terminology fits within the paradigm of medicine and allows those in the medical field to grasp the root concepts that have been spoken for the last several hundred to four thousand years. Only now is the science finally catching up to what has been spoken by the elders in those professions.