Kitasato Shibasaburō (1853–1931) studied bacteriology in Germany under Robert Koch. In 1891 he founded the Institute of Infectious Diseases in Tokyo, which introduced the study of bacteriology to Japan. He and French researcher Alexandre Yersin went to Hong Kong in 1894, where; Kitasato confirmed Yersin's discovery that the bacterium Yersinia pestis is the agent of the plague. In 1897 he isolates and described the organism that caused dysentery. He became the first dean of medicine at Keio University, and the first president of the Japan Medical Association.[147][148]

In London, the crown allowed two hospitals to continue their charitable work, under nonreligious control of city officials.[96] The convents were all shut down but Harkness finds that women—some of them former nuns—were part of a new system that delivered essential medical services to people outside their family. They were employed by parishes and hospitals, as well as by private families, and provided nursing care as well as some medical, pharmaceutical, and surgical services.[97]
This week on the Evolution of Podcast, we feature Dr. Joel Baumgartner and JR Burgess of Rejuv Medical as part of our Future of Patient Compliance series. At the corner of exercise and medicine, sits a huge opportunity to develop the health creation centers of the future. JR and Dr. Baumgartner have come together to create Rejuv Medical which allows doctors to incorporate medical fitness to their practices.
This week on the Evolution ​of Medicine podcast, we are back with the fifth installment of the "State of the Evolution" with co-founders of the Evolution of Medicine, James Maskell and Gabe Hoffman.  Twice a year we look back at ground take-in the last six months and look forward to the next six. We're excited to share with you what's happened and what to expect during the first half of 2017.
James Maskell:  Yeah, absolutely, it was great.  You know, we have a whole day based on the evolution of nutrition.  It includes you and Terry Wahls, talking about the nutrition side.  But we also have Food Babe in there because she’s not really in the Paleo world, but I think a big part of the evolution of nutrition is to really get active and find out what’s in the food.  And I really commend her.  I think she’s playing a big role in sort of holding some of these food companies accountable.  And I think activism is an important part of making sure that we do have good options in the future.  So she’s included on that day.  And then Darryl Edwards, who does his Primal Play. He’s just a great guy, another English guy.  He’s going to be talking about the evolution of exercise.  I had an opportunity to do one of his Primal Play sessions in Central Park.  And I can tell you, I was hurting the next day and the day after, in places that I didn’t realize I had muscles.

Contemporary humans in developed countries are mostly free of parasites, particularly intestinal ones. This is largely due to frequent washing of clothing and the body, and improved sanitation. Although such hygiene can be very important when it comes to maintaining good health, it can be problematic for the proper development of the immune system. The hygiene hypothesis is that humans evolved to be dependent on certain microorganisms that help establish the immune system, and modern hygiene practices can prevent necessary exposure to these microorganisms. "Microorganisms and macroorganisms such as helminths from mud, animals, and feces play a critical role in driving immunoregulation" (Rook, 2012[26]). Essential microorganisms play a crucial role in building and training immune functions that fight off and repel some diseases, and protect against excessive inflammation, which has been implicated in several diseases. For instance, recent studies have found evidence supporting inflammation as a contributing factor in Alzheimer's Disease.[27]

In the 1950s new psychiatric drugs, notably the antipsychotic chlorpromazine, were designed in laboratories and slowly came into preferred use. Although often accepted as an advance in some ways, there was some opposition, due to serious adverse effects such as tardive dyskinesia. Patients often opposed psychiatry and refused or stopped taking the drugs when not subject to psychiatric control. There was also increasing opposition to the use of psychiatric hospitals, and attempts to move people back into the community on a collaborative user-led group approach ("therapeutic communities") not controlled by psychiatry. Campaigns against masturbation were done in the Victorian era and elsewhere. Lobotomy was used until the 1970s to treat schizophrenia. This was denounced by the anti-psychiatric movement in the 1960s and later.

During the 18th century medicine made slow progress. Doctors still did not know what caused disease. Some continued to believe in the four humors (although this theory declined during the 18th century). Other doctors thought disease was caused by 'miasmas' (odorless gases in the air). However surgery did make some progress. The famous 18th century surgeon John Hunter (1728-1793) is sometimes called the Father of Modern Surgery. He invented new procedures such as tracheotomy.

^ Heeßel, N. P. (2004). "Diagnosis, Divination, and Disease: Towards an Understanding of the Rationale Behind the Babylonian Diagonostic Handbook". In Horstmanshoff, H.F. .; Stol, Marten; Tilburg, Cornelis. Magic and Rationality in Ancient Near Eastern and Graeco-Roman Medicine. Studies in Ancient Medicine. 27. Leiden, The Netherlands: Brill. pp. 97–116. ISBN 978-9004136663.
c. 484 – 425 BC – Herodotus tells us Egyptian doctors were specialists: Medicine is practiced among them on a plan of separation; each physician treats a single disorder, and no more. Thus the country swarms with medical practitioners, some undertaking to cure diseases of the eye, others of the head, others again of the teeth, others of the intestines,and some those which are not local.[5]
One of the things that James learned last week is that he has “perfect detoxification pathways”, but not all people are so lucky. A huge topic of discussion on the upcoming Summit is MTHFR. Methylene tetrahydrofolate reductase is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene. This week we welcome Sterling Hill, the founder of Sterling is an educator and having found out of her personal status and what it means for her - she has been educating others about the impact of MTHFR for years.
James Maskell:  Yeah.  Well, obviously, you have, some of the ideas you talked about there are perfect I think. I just wrote a blog for The ZocDoc Blog about why doctors should curate their patient education.  And curating resources is much more efficient than just telling people stuff.  You don’t need people to do that, you just need to use the resources that are available.  And so actually, one of the ways that we designed this summit was that it would be almost like the perfect thing for a doctor to curate for their patient—because there is a patient track.  It’s going to basically teach the patient how to be a great patient and how to look after the four major modifiable causes of chronic disease: diet and stress, toxicity, immunity, and the microbiome.  These are all things that patients have the majority of control over.  This is not medicine that’s done to you.  And so, we were just—so that’s part of the track in the doctor track.  I think the curation of patient education can take a lot of the time out of the appointments, because you see one of the biggest things about functional medicine is that it takes a lot of time to do it, because you have to listen and so forth.  So that’s one of the things.  But like you said, technology can play a key role.  And we have doctors in the summit that are talking about how they’re using technology even in poorer, rural areas of the country, where they’re building community-orientated practices that serve a blue-collar type of patient, and it’s working.  And if it could work in rural Indiana, it can work anywhere.  And that’s really exciting.  You know, our vision for this, Chris, is just a nationwide network of remarkable community-orientated functional practices.  In the same ways you saw the natural response to Walmart was farmers’ markets—you know, going directly to the farmer and having that direct interaction—I think the natural reaction to big medicine is these small micropractices that deliver exceptional value to patients in local areas into the community.
The authors also provide examples of how evolutionary principles can direct future research. They reference new research looking into the role of intestinal parasites and autoimmune diseases. The research is based upon the premise that humans co-evolved not only with our intestinal flora, but with certain parasites, such as intestinal worms. Now we live in a largely hygienic environment, and have even taken steps to eliminate parasites. This may have unintentionally deprived our immune systems of needed stimulation, resulting in poor immune regulation, and subsequent increase in auto-immune diseases like asthma and multiple sclerosis.
^ England and Wales had nine county and borough asylums in 1827 with an average capacity of a little over 100 patients, but by 1890 there were 66 such asylums containing on average 800 patients each;[182] the total number of patients so confined increased from 1,027 in 1827 to 74,004 in 1900.[183] Similarly, in Germany, between 1852 and 1898 the asylum population increased seven-fold from 11,622 to 74,087 patients during a period when the total population had only grown by ten per cent.[158] In America the asylum population had risen to almost 250,000 on the eve of the First World War.[184]
Being a king in ancient times was exhaustingly dangerous; there was always someone plotting to get rid of you. So, according to legend, Mithradates (aka Mithridates) VI of Pontus (on the shores of the Black Sea in Turkey) attempted to become resistant to poisons by taking gradually increasing doses. He was also reputed to have conducted toxicological experiments on condemned prisoners, culminating in the creation of mithridate – a medicine that combined all known antidotes in one potent formula.
Across Europe medical schools relied primarily on lectures and readings. The final year student would have limited clinical experience by trailing the professor through the wards. Laboratory work was uncommon, and dissections were rarely done because of legal restrictions on cadavers. Most schools were small, and only Edinburgh, Scotland, with 11,000 alumni, produced large numbers of graduates.[99][100]

Small Intestinal Bacteria Overgrowth - it's become a buzzword in medicine the past few years and Chris has been on the cutting edge of treating it. We'll be discussing the standard diagnosis, why it's problematic, and what we can do about it. There podcast has tons of value for practitioners who are on the front lines of dealing with a range of digestive and other related issues. 

At the same time Greek doctors developed a rational theory of disease and sought cures. However one did not replace the other. The cult of Asclepius and Greek medicine existed side by side. Medical schools were formed in Greece and in Greek colonies around the Mediterranean. As early as 500 BC a man named Alcmaeon from Croton in Italy said that a body was healthy if it had the right balance of hot and cold, wet and dry. It the balance was upset the body grew ill. However the most famous Greek doctor is Hippocrates (C.460-377 BC). (Although historians now believe that he was much less famous in his own time that was once thought. It is believed that many of the medical books ascribed to him were actually written by other men). Hippocrates stressed that doctors should carefully observe the patients symptoms and take note of them. Hippocrates also rejected all magic and he believed in herbal remedies.
Medical education instituted at the Royal and Pontifical University of Mexico chiefly served the needs of urban elites. Male and female curanderos or lay practitioners, attended to the ills of the popular classes. The Spanish crown began regulating the medical profession just a few years after the conquest, setting up the Royal Tribunal of the Protomedicato, a board for licensing medical personnel in 1527. Licensing became more systematic after 1646 with physicians, druggists, surgeons, and bleeders requiring a license before they could publicly practice.[108] Crown regulation of medical practice became more general in the Spanish empire.[109]
I’m really excited to have James Maskell from Functional Forum and Revive Primary Care.  He’s also the director of the Evolution of Medicine Summit just coming up that I’m participating in.  I asked James to come on this show so we could chat about functional medicine and the future of medicine in general, because there are some really big and exciting changes happening in the world of medicine and functional medicine in particular, and James has his hands in a lot of different pots in this field.
After the atomic bombing at the end of World War II, anxieties about survival in the nuclear age led scientists to begin stockpiling and freezing hundreds of thousands of blood samples from indigenous communities around the world. These samples were believed to embody potentially invaluable biological information about genetic ancestry, evolution, microbes, and much more. In Life on Ice, Joanna Radin examines how and why these frozen blood samples shaped the practice known as biobanking.
1867 Joseph Lister publishes Antiseptic Principle of the Practice of Surgery, one of the most important developments in medicine. Lister was convinced of the need for cleanliness in the operating room, a revolutionary idea at the time. He develops antiseptic surgical methods, using carbolic acid to clean wounds and surgical instruments. The immediate success of his methods leads to general adoption. In one hospital that adopts his methods, deaths from infection decrease from nearly 60% to just 4%.
This was a common scenario in wars from time immemorial, and conditions faced by the Confederate army were even worse. The Union responded by building army hospitals in every state. What was different in the Union was the emergence of skilled, well-funded medical organizers who took proactive action, especially in the much enlarged United States Army Medical Department,[135] and the United States Sanitary Commission, a new private agency.[136] Numerous other new agencies also targeted the medical and morale needs of soldiers, including the United States Christian Commission as well as smaller private agencies.[137]
In East Semitic cultures, the main medicinal authority was a kind of exorcist-healer known as an āšipu.[8][9][10] The profession was generally passed down from father to son[8] and was held in extremely high regard.[8] Of less frequent recourse was another kind of healer known as an asu, who corresponds more closely to a modern physician[7] and treated physical symptoms using primarily folk remedies composed of various herbs, animal products, and minerals, as well as potions, enemas, and ointments or poultices.[7] These physicians, who could be either male or female, also dressed wounds, set limbs, and performed simple surgeries.[7] The ancient Mesopotamians also practiced prophylaxis[7] and took measures to prevent the spread of disease.[7]
^ Nesse RM, Bergstrom CT, Ellison PT, Flier JS, Gluckman P, Govindaraju DR, Niethammer D, Omenn GS, Perlman RL, Schwartz MD, Thomas MG, Stearns SC, Valle D (January 2010). "Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine". Proceedings of the National Academy of Sciences of the United States of America. 107. 107 Suppl 1 (suppl_1): 1800–7. doi:10.1073/pnas.0906224106. PMC 2868284. PMID 19918069.
Galen's medical works were regarded as authoritative until well into the Middle Ages. Galen left a physiological model of the human body that became the mainstay of the medieval physician's university anatomy curriculum, but it suffered greatly from stasis and intellectual stagnation because some of Galen's ideas were incorrect; he did not dissect a human body.[53] Greek and Roman taboos had meant that dissection was usually banned in ancient times, but in the Middle Ages it changed.[54][55]
3 Schwarz, Richard W. “John Harvey Kellogg, M.D.: Pioneering Health Reformer.” John Harvery Kellogg, M.D.: Pioneering Health Reformer – Richard W. Schwarz – Google Books. Google Books, 2006. Web. 26 Jan. 2014. .
Evolutionary principles may also improve our vaccine strategy. Vaccines are another way to create selective pressures on infectious organisms. We may inadvertently target vaccines against proteins that select out less virulent strains, selecting for the more virulent or infectious strains. Understanding of this allows us to instead target vaccines against virulence without targeting less deadly strains.
One of the oldest known medical textbooks is the Sushruta Samhita, written in Sanskrit in India. Its exact date is tentative, as no original version survives and it is only known from later copies, but the current consensus is that it was written in around 600 BC. Sushruta is thought to have been a physician and teacher working in the North Indian city of Benares (now Varanasi in the state of Uttar Pradesh). His Samhita – a compilation of knowledge – provides detailed information on medicine, surgery, pharmacology and patient management.
Mac shares how Nudge Coach provides an efficient and effective way to better coaching and accountability for patients once they step out of the doctor's office. If you've been following us for awhile, you know that we have now moved from the term "compliance" to "empowerment".  In this podcast, we discuss the difference between the two terms and how we have evolved passed some of the old verbiage into a new relationship between the patient and practitioner. 

This week’s podcast features: Daniel Schmachtenburger, co-founder and director of research and development at Neurohacker Collective, in Complexity Medicine: The Basis for a Functional Standard of Care. Daniel is a deep thinker and researcher on how human regulatory systems function, how they break down and how they can be supported to function with greater resilience.