1656 Experimenting on dogs, English architect Sir Christopher Wren is the first to administer medications intravenously by means of an animal bladder attached to a sharpened quill. Wren also experiments with canine blood transfusions (although safe human blood transfusions only became feasible after Karl Landsteiner develops the ABO blood-typing system in 1900).
In the Middle Ages learning flourished in Europe. Greek and Roman books, which had been translated into Arabic were now translated into Latin. In the late 11th century a school of medicine was founded in Salerno in Italy. (Women were allowed to study there as well as men). In the 12th century another was founded at Montpellier. In the 13th century more were founded at Bologna, Padua and Paris. Furthermore many students studied medicine in European universities. Medicine became a profession again. However ordinary people could not afford doctors fees. Instead they saw 'wise men' or 'wise women',
It didn’t work against Roman armies, however, and when Mithradates was defeated by the military leader Pompey in 66 BC, the recipe supposedly arrived in Rome. Emperor Nero’s physician Andromachus developed it into a 64-ingredient composition, which became known as theriac. Most of the ingredients were botanical (including opium), but viper’s flesh was a notable component.
I ended up selling the practice to my partner and taking a 20-month sabbatical due to a motor vehicle accident. I had considered retiring after selling the practice, but in the area where I live there are very few people practicing this style of medicine and the need far exceeds the number of people who have the skills or knowledge. During the time I was not working, I had many former patients contacting me and wanting to know when I was going to open a new practice.
So much great stuff here in how to build a low overhead practice, some of the technology that she's learned how to use through the Evolution of Medicine Practice Accelerator, how to keep a low overhead practice, how to build a connection with local integrative providers that now pay her rent, and just so many other ways in which Sonza has built such an amazing practice. I think there's value in here, no matter what kind of practitioner you are, and I really hope you'll enjoy it. This is part of our Success Leaves Clues podcast series, enjoy.
Some 200 years later another doctor, Peseshet, was immortalised on a monument in the tomb of her son, Akhet-Hetep (aka Akhethetep), a high priest. Peseshet held the title ‘overseer of female physicians’, suggesting that women doctors weren’t just occasional one-offs. Peseshet herself was either one of them or a director responsible for their organisation and training.
However, this all changed with Hippocrates, one of the most famous of all physicians, and his famous oath is still used by doctors today, as they pledge to 'Do No Harm.' His most telling contribution to the history of medicine was the separation of medicine from the divine, and he believed that checking symptoms, giving diagnoses and administering treatment should be separated from the rituals of the priests, although most Greeks were happy to combine the two and hedge their bets.
In this episode, we followed on from last week's Functional Forum and talked about the role of education in the future of medicine, and particularly the role of delivery of content. Danny introduces us to a great resource for practitioners who are interested in creating dynamic content. The book is available for download May 4th through May 8th at goevomed.com/teach. If you're listening to this podcast between May 4th and May 8th, go get it right now. We had a great half-an-hour discussion. Send us your thoughts and feedback!
^ Nesse RM, Bergstrom CT, Ellison PT, Flier JS, Gluckman P, Govindaraju DR, Niethammer D, Omenn GS, Perlman RL, Schwartz MD, Thomas MG, Stearns SC, Valle D (January 2010). "Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine". Proceedings of the National Academy of Sciences of the United States of America. 107. 107 Suppl 1 (suppl_1): 1800–7. doi:10.1073/pnas.0906224106. PMC 2868284. PMID 19918069.
all biological traits need two kinds of explanation, both proximate and evolutionary. The proximate explanation for a disease describes what is wrong in the bodily mechanism of individuals affected by it. An evolutionary explanation is completely different. Instead of explaining why people are different, it explains why we are all the same in ways that leave us vulnerable to disease. Why do we all have wisdom teeth, an appendix, and cells that can divide out of control?
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Louis Pasteur (1822–1895) was one of the most important founders of medical microbiology. He is remembered for his remarkable breakthroughs in the causes and preventions of diseases. His discoveries reduced mortality from puerperal fever, and he created the first vaccines for rabies and anthrax. His experiments supported the germ theory of disease. He was best known to the general public for inventing a method to treat milk and wine in order to prevent it from causing sickness, a process that came to be called pasteurization. He is regarded as one of the three main founders of microbiology, together with Ferdinand Cohn and Robert Koch. He worked chiefly in Paris and in 1887 founded the Pasteur Institute there to perpetuate his commitment to basic research and its practical applications. As soon as his institute was created, Pasteur brought together scientists with various specialties. The first five departments were directed by Emile Duclaux (general microbiology research) and Charles Chamberland (microbe research applied to hygiene), as well as a biologist, Ilya Ilyich Mechnikov (morphological microbe research) and two physicians, Jacques-Joseph Grancher (rabies) and Emile Roux (technical microbe research). One year after the inauguration of the Institut Pasteur, Roux set up the first course of microbiology ever taught in the world, then entitled Cours de Microbie Technique (Course of microbe research techniques). It became the model for numerous research centers around the world named "Pasteur Institutes."
James Maskell: Yeah. Well, obviously, you have, some of the ideas you talked about there are perfect I think. I just wrote a blog for The ZocDoc Blog about why doctors should curate their patient education. And curating resources is much more efficient than just telling people stuff. You don’t need people to do that, you just need to use the resources that are available. And so actually, one of the ways that we designed this summit was that it would be almost like the perfect thing for a doctor to curate for their patient—because there is a patient track. It’s going to basically teach the patient how to be a great patient and how to look after the four major modifiable causes of chronic disease: diet and stress, toxicity, immunity, and the microbiome. These are all things that patients have the majority of control over. This is not medicine that’s done to you. And so, we were just—so that’s part of the track in the doctor track. I think the curation of patient education can take a lot of the time out of the appointments, because you see one of the biggest things about functional medicine is that it takes a lot of time to do it, because you have to listen and so forth. So that’s one of the things. But like you said, technology can play a key role. And we have doctors in the summit that are talking about how they’re using technology even in poorer, rural areas of the country, where they’re building community-orientated practices that serve a blue-collar type of patient, and it’s working. And if it could work in rural Indiana, it can work anywhere. And that’s really exciting. You know, our vision for this, Chris, is just a nationwide network of remarkable community-orientated functional practices. In the same ways you saw the natural response to Walmart was farmers’ markets—you know, going directly to the farmer and having that direct interaction—I think the natural reaction to big medicine is these small micropractices that deliver exceptional value to patients in local areas into the community.
In the 17th century medicine was helped by the microscope (invented at the end of the 16th century). Then in 1665 Robert Hooke was the first person to describe cells in his book Micrographia. Finally in 1683 Antonie van Leeuwenhoek observed microorganisms. However he did not realise they caused disease. Meanwhile in 1661 Robert Boyle published the Skeptical Chemist, which laid the foundations of modern chemistry. In the early 17th century doctors also discovered how to treat malaria with bark from the cinchona tree (it contains quinine).
This week on the Evolution of Medicine podcast, we are excited to welcome Qigong master Mingtong Gu, recorded live from his center in New Mexico with Evolution of Medicine co-founder Gabe Hoffman. Gabe has been studying Wisdom Healing Qigong with Mingtong since finding his high-quality content on YouTube two years ago. Since then Gabe learned of the extremely successful Medicineless Qigong Hospital in China, where Wisdom Healing Qigong is the only tool used. Gabe recently returned from a month-long retreat, led by Mingtong, where people with all types of chronic disease used the same protocols as the hospital in China with great success.
Utilizing the Delphi method, 56 experts from a variety of disciplines, including anthropology, medicine, and biology agreed upon 14 core principles intrinsic to the education and practice of evolutionary medicine. These 14 principles can be further grouped into five general categories: question framing, evolution I and II (with II involving a higher level of complexity), evolutionary trade-offs, reasons for vulnerability, and culture. Additional information regarding these principles may be found in the table below.
Chris Kresser: Yeah, that’s really exciting to me. I think another frontier is lab testing. I mean, that’s one of the, as a practitioner, that’s one of the things that troubles me the most, is how expensive these labs are. And in a lot of cases, the insurance isn’t covering them because they don’t deem them to be medically necessary, which just makes me want to pull my hair out, because of course, you know, if we do these labs and we identify the underlying problems initially, we’re potentially heading off tens of thousands of dollars, if not more, in medical costs to the insurance company later on down the line. So I guess it just depends on how you define medically necessary, but that’s a whole different discussion. Some of these labs can be hundreds or even thousands of dollars. So I know there are some pretty exciting, new movements out there to make this lab testing more affordable financially. And then some of the tech tools that are becoming available, like the Quantified Self Revolution, that could really help in terms of not only gathering the necessary data, but organizing it and then presenting it back to the clinician in a way that makes sense and makes it easy for the clinician to track progress. So I know this is an area of interest for both us, James. Maybe you could talk a little bit about some of them, the more exciting technologies that you’ve seen, and that people have talked about in the summit.
The Nightingale model was widely copied. Linda Richards (1841–1930) studied in London and became the first professionally trained American nurse. She established nursing training programs in the United States and Japan, and created the first system for keeping individual medical records for hospitalized patients. The Russian Orthodox Church sponsored seven orders of nursing sisters in the late 19th century. They ran hospitals, clinics, almshouses, pharmacies, and shelters as well as training schools for nurses. In the Soviet era (1917–1991), with the aristocratic sponsors gone, nursing became a low-prestige occupation based in poorly maintained hospitals.
James Maskell: Yeah, absolutely. And it’s cool as well. So in this summit, we have a doctor track as well as a patient track. And in the doctor track, we’re actually talking about some of the ways that this is actually being delivered. And there are ways to deliver functional medicine on insurance. We’re featuring the group visit model in one of the doctor-specific tracks. That’s been very successful at bringing people together, developing a community around groups of people with the same disease. They want accountability. They want support. They want to hear from other people that have the same issues as them. So that’s working and that’s going to be included in the functional center at Cleveland Clinic. And then also health coaches. They’re looking at using different providers together, so you can have higher-cost and lower-cost providers working together. So it’s really exciting. I feel like once we get more and more organizations doing it that are credible, people will work out how to get this done on insurance and how to do this at a bigger scale. The first thing is just the clinical acceptance that’s been a long time coming.
The paper of Paul Ewald in 1980, “Evolutionary Biology and the Treatment of Signs and Symptoms of Infectious Disease”, and that of Williams and Nesse in 1991, “The Dawn of Darwinian Medicine” were key developments. The latter paper “draw a favorable reception”,page x and led to a book, Why We Get Sick (published as Evolution and healing in the UK). In 2008, an online journal started: Evolution and Medicine Review.
Last time we featured her, the Evolution of Medicine community showed support and interest that made a real difference. Thank you! We bring her back this week to share an update about Organize. She and her team were recently at the White House to speak about their project with some important influencers from the industry. She shares with us what she learned and what they were able to accomplish.
Although there is no record to establish when plants were first used for medicinal purposes (herbalism), the use of plants as healing agents, as well as clays and soils is ancient. Over time through emulation of the behavior of fauna a medicinal knowledge base developed and passed between generations. As tribal culture specialized specific castes, shamans and apothecaries fulfilled the role of healer. The first known dentistry dates to c. 7000 BC in Baluchistan where Neolithic dentists used flint-tipped drills and bowstrings. The first known trepanning operation was carried out c. 5000 BC in Ensisheim, France. A possible amputation was carried out c. 4,900 BC in Buthiers-Bulancourt, France.
Later in Roman times Galen (130-200 AD) became a famous doctor. At first he worked treating wounded gladiators. Then in 169 AD he was made doctor to Commodus, the Roman Emperor's son. Galen was also a writer and he wrote many books. Galen believed the theory of the four humors. He also believed in treating illness with opposites. So if a patient had a cold Galen gave him something hot like pepper. Galen was also interested in anatomy. Unfortunately by his time dissecting human bodies was forbidden. So Galen had to dissect animal bodies including apes. However animal bodies are not the same as human bodies and so some of Galen's ideas were quite wrong. Unfortunately Galen was a very influential writer. For centuries his writings dominated medicine.
History Timelines of Events provide fast facts and information about famous events in history, such as those detailed in the History of Medicine Timeline, precipitated a significant change in World history. This major historical event is arranged in the History of Medicine timeline by chronological, or date order, providing an actual sequence of this past event which was of significance to history. Many historical events, such as detailed in the History of Medicine timeline, occurred during times of crisis or evolution or change. Many of the famous World events as detailed in the History of Medicine timeline describe famous, critical and major incidents. The specific period in history detailed in the History of Medicine timeline led to great changes in the development of World Civilisation. The History of Medicine timeline provides fast information via timelines which highlight the key dates and major historical significance in a fast information format. Specific information can be seen at a glance with concise and accurate details of this historical event of World significance. The History timelines of famous events include timelines and chronologies of many important events of significant occurrence and outcome including the History of Medicine timeline.
A leading journal in its field for more than three quarters of a century, the Bulletin spans the social, cultural, and scientific aspects of the history of medicine worldwide. Every issue includes reviews of recent books on medical history. Recurring sections include Digital Media & Humanities and Pedagogy. Bulletin of the History of Medicine is the official publication of the American Association for the History of Medicine (AAHM) and the Johns Hopkins Institute of the History of Medicine.
Modern research has shown that these builders were not slaves but highly respected and well-treated freemen, and the care and treatment given for injuries and afflictions was centuries ahead of its time. Early paid retirement, in case of injury, and sick leave were some of the farsighted policies adopted by Ancient Egyptian medicine, luxuries that would rarely be enjoyed by most workers until well into the 20th Century.